This trial is studying whether intensive medication treatment can reduce heart problems in women with symptoms of heart disease but without major artery blockages. This trial involves 4,422 women who will either receive intensive treatment with statins, ACE inhibitors (or ARBs), and aspirin, or usual care. The study aims to see if intensive treatment can lower the risk of death, heart attacks, strokes, or hospitalizations for heart-related issues by 20% compared to usual care.